6-[3-(1-adamantyl)-4-methoxy-phenyl]naphthalene-2-carboxylic Acid CAS 106685-40-9

Product Description

Product Name: 6-[3-(1-adamantyl)-4-methoxy-phenyl]naphthalene-2-carboxylic acid CAS NO: 106685-40-9

Synonyms:

Adapalene;

Adapalenum;

Differin;

6-[3-(1-Adamantyl)-4-methoxyphenyl]-2-naphthoic Acid;

6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid;

2-Naphthalenecarboxylic acid, 6-(4-methoxy-3-tricyclo[3.3.1.1]dec-1-ylphenyl)-;

6-[3-(Adamantan-1-yl)-4-methoxyphenyl]-2-naphthoic acid;

Adapaleno;

Adaferin;

Chemical & Physical Properties

Appearance : white to off-white powder

Assay :≥99.0%

Solubility: DMSO: >10mg/mL

Density:1.233 g/cm3

Boiling Point:606.3℃ at 760 mmHg

Melting Point: 319-322℃

Flash Point:205.9℃

Refractive Index:1.654

Vapor Pressure:1.49E-15mmHg at 25°C

Adapalene(CD-271; Differin), a synthetic retinoid, is a retinoic acid receptor agonist (RAR).Target: Retinoic acid receptor agonist (RAR)Adapalene is a third-generation topical retinoid primarily used in the treatment of mild-moderate acne and is also used (off-label) to treat keratosis pilaris as well as other skin conditions. Adapalene is possibly more effective than tretinoin 0.025% gel in the treatment of acne vulgaris.

Thirty-six rats of either sex were divided into six groups (two control groups, and an etodolac, indomethacin, tretinoin and adapalene group) of six animals each. Each group was given different drugs or chemicals. The inhibitory activities of the drugs were determined on carrageenan-induced rat-paw oedema. The inhibition rate (53.48%) in the tretinoin group was found to be higher thanadapalene and controls (P < 0.05).="" adapalene="" was="" found="" to="" have="" an="" inhibition="" rate="" of="" 10.28%,="" and="" when="" compared="" with="" the="" other="" groups,="" was="" found="" to="" have="" no="" statistically="" significant="" anti-inflammatory="">

If you are interested in our products or have any questions, please feel free to contact us!

Products under patent are offered for R & D purpose only. However, the final responsibility lies exclusively with the buyer.

Populární Tagy: 6-[3-(1-adamantyl)-4-methoxy-phenyl]naphthalene-2-carboxylic acid cas 106685-40-9, manufacturers, suppliers, factory, buy, in stock

• Dvojice: 1- (5- bromo -2- methoxy - fenyl) adamantan CAS 104224 - 63 - 7
• Další: 3,4-dihydro-2H-pyrrol-5-amin hydrochlorid CAS 7544-75-4